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Iris Valera Larios about blood disorder ITP treatments : What are platelets? There are three types of blood cell which are all formed in the bone marrow; red cells, white cells and platelets. Platelets, which are small and sticky and circulate in the bloodstream provide the inital plug to stop bruising and bleeding after an injury, and stop blood leaking from capilleries. A blood sample is taken to measure the circulating platelets, and in most people there are between 150,000 and 400,000 platelets in every cubic millimetre of blood. However in the USA we simplify this by describing a platelet count of, say, 150 rather than 150,000. Anyone with a count less than 100 would be considered thrombocytopenic (ie. short of platelets).
How is ITP diagnosed? ITP is usually diagnosed by a blood test showing that only the platelet count is low, and the platelets, red blood cells and white blood cells all look normal. A bone marrow biopsy may be taken at a later stage if the ITP continues, in which a small sample of bone marrow will be taken under local anaesthetic and examined under the microscope. Additional blood tests may be taken at this time to exclude rare clotting or immune diseases that can mimic ITP. If the bone marrow looks normal, with the usual or higher number of platelet parent cells (megakaryocytes) and other blood tests are normal then the doctor will diagnose chronic ITP.
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What is immune thrombocytopenia (ITP)? ITP is a medical term for a condition in which there is bruising or bleeding because there are fewer platelets in the blood than usual (thrombocytopenia) and is usually caused by something going wrong with the immune system (the body’s defence against infection). ITP is not a genetic/inherited condition. How common is ITP and who does it affect? Approximately 4 in every 100,000 people develop ITP every year. It can occur at any age but is slightly more common in women than men.
Careful review of your medications: Historically, a bone marrow aspiration was required to make a diagnosis of ITP. It may not be absolutely necessary in the face of a positive antiplatelet antibody test, but it is still commonly done to look at the production of platelets and to rule out any abnormal cells the marrow may be producing that could lower platelet counts. A bone marrow aspiration is necessary for a diagnosis if the antiplatelet antibody testing is negative. Read additional information on Iris Valera Larios.
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Medications (including over-the-counter medications) can cause an allergy that cross-reacts with platelets. Infections, typically viral infections, including the viruses that cause chicken pox, hepatitis C, and AIDS, can prompt antibodies that cross-react with platelets. Pregnancy, Immune disorders, such as rheumatoid arthritis and lupus, Low-grade lymphomas and leukemias may produce abnormal antibodies against platelet proteins. Sometimes the cause of immune thrombocytopenic purpura is not known.